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Targeting MicroRNA-192–5p, a Downstream Effector of NOXs, Reverses Endothelial Dihydrofolate Reductase Deficiency to Attenuate Abdominal Aortic Aneurysm Formation
We have shown that endothelial specific dihydrofolate reductase (DHFR) deficiency underlies eNOS uncoupling and formation of abdominal aortic aneurysm (AAA). Here we examined a novel role of miR-192–5p in mediating NOX-dependent DHFR deficiency and AAA formation. miR-192–5p is predicted to target DH...
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| Udgivet i: | Hypertension |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8266749/ https://ncbi.nlm.nih.gov/pubmed/34176283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15070 |
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