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RAG gene defects at the verge of immunodeficiency and immune dysregulation

Mutations of the Recombinase Activating Genes (RAG) in humans underlie a broad spectrum of clinical and immunological phenotypes that reflect different degrees of impairment of T and B cell development and alterations of mechanisms of central and peripheral tolerance. Recent studies have shown that...

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Detalhes bibliográficos
Publicado no:Immunol Rev
Main Authors: Villa, Anna, Notarangelo, Luigi D
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309314/
https://ncbi.nlm.nih.gov/pubmed/30565244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imr.12713
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