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PKCθ via Activating Transcription Factor 2-mediated CD36 Expression and Foam Cell Formation of Ly6C(hi) Cells Contributes to Atherosclerosis

BACKGROUND: Although the role of thrombin in atherothrombosis is well studied, its role in the pathogenesis of diet-induced atherosclerosis is not known. METHODS: Using a mouse model of diet-induced atherosclerosis and molecular biological approaches, here we have explored the role of thrombin and i...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Raghavan, Somasundaram, Singh, Nikhlesh K., Gali, Sivaiah, Mani, Arul M., Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309268/
https://ncbi.nlm.nih.gov/pubmed/29991487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.034083
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