Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of Down syndrome

Cystatin C (CysC) plays diverse protective roles under conditions of neuronal challenge. We investigated whether CysC protects from trisomy-induced pathologies in a mouse model of Down syndrome (DS), the most common cause of developmental cognitive and behavioral impairments in humans. We have previ...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Kaur, Gurjinder, Gauthier, Sebastien A., Perez-Gonzalez, Rocio, Pawlik, Monika, Singh, Amol Bikram, Cosby, Benjamin, Mohan, Panaiyur V., Smiley, John F., Levy, Efrat
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309243/
https://ncbi.nlm.nih.gov/pubmed/30176349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.08.025
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