Cystatin C Rescues Degenerating Neurons in a Cystatin B-Knockout Mouse Model of Progressive Myoclonus Epilepsy

In vitro studies have shown that cystatin C (CysC) is neuroprotective. Here we demonstrate that CysC is neuroprotective in vivo, in a mouse model of the inherited neurodegenerative disorder, progressive myoclonic epilepsy type 1 (EPM1). Loss-of-function mutations in the cystatin B (CysB) gene, an in...

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Библиографические подробности
Главные авторы: Kaur, Gurjinder, Mohan, Panaiyur, Pawlik, Monika, DeRosa, Steven, Fajiculay, Jay, Che, Shaoli, Grubb, Anders, Ginsberg, Stephen D., Nixon, Ralph A., Levy, Efrat
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2010
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Regular Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966785/
https://ncbi.nlm.nih.gov/pubmed/20889561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100461
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