Apolipoprotein E4 genotype compromises brain exosome production

In addition to being the greatest genetic risk factor for Alzheimer's disease, expression of the ɛ4 allele of apolipoprotein E can lead to cognitive decline during ageing that is independent of Alzheimer's amyloid-β and tau pathology. In human post-mortem tissue and mouse models humanized...

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Dades bibliogràfiques
Publicat a:Brain
Autors principals: Peng, Katherine Y, Pérez-González, Rocío, Alldred, Melissa J, Goulbourne, Chris N, Morales-Corraliza, Jose, Saito, Mariko, Saito, Mitsuo, Ginsberg, Stephen D, Mathews, Paul M, Levy, Efrat
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308312/
https://ncbi.nlm.nih.gov/pubmed/30496349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy289
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