Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease

Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The excessive activity of AChE causes various neuronal problems, particularly dementia and neuronal cell deaths. Generally, anti-AChE drugs induce some serious neuronal side effects in humans. Therefore, this study...

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Vydáno v:J Pharm Anal
Hlavní autoři: Vijayakumar, Subramaniyan, Manogar, Palani, Prabhu, Srinivasan, Sanjeevkumar Singh, Ram Avadhar
Médium: Artigo
Jazyk:Inglês
Vydáno: Xi'an Jiaotong University 2018
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308024/
https://ncbi.nlm.nih.gov/pubmed/30595949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2017.07.006
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