Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease

Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The excessive activity of AChE causes various neuronal problems, particularly dementia and neuronal cell deaths. Generally, anti-AChE drugs induce some serious neuronal side effects in humans. Therefore, this study...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharm Anal
Hauptverfasser: Vijayakumar, Subramaniyan, Manogar, Palani, Prabhu, Srinivasan, Sanjeevkumar Singh, Ram Avadhar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Xi'an Jiaotong University 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308024/
https://ncbi.nlm.nih.gov/pubmed/30595949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2017.07.006
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