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Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease

Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The excessive activity of AChE causes various neuronal problems, particularly dementia and neuronal cell deaths. Generally, anti-AChE drugs induce some serious neuronal side effects in humans. Therefore, this study...

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Detalhes bibliográficos
Publicado no:J Pharm Anal
Main Authors: Vijayakumar, Subramaniyan, Manogar, Palani, Prabhu, Srinivasan, Sanjeevkumar Singh, Ram Avadhar
Formato: Artigo
Idioma:Inglês
Publicado em: Xi'an Jiaotong University 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308024/
https://ncbi.nlm.nih.gov/pubmed/30595949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2017.07.006
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