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Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts
X-chromosome inactivation (XCI) provides a dosage compensation mechanism where, in each female cell, one of the two X chromosomes is randomly silenced. However, some genes on the inactive X chromosome and outside the pseudoautosomal regions escape from XCI and are expressed from both alleles (escape...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6304968/ https://ncbi.nlm.nih.gov/pubmed/30510006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806811115 |
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