Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

Children with Down syndrome (DS) and acute lymphoblastic leukaemia (ALL) have poorer survival and more relapses, than non-DS children with ALL, highlighting an urgent need for deeper mechanistic understanding of DS-ALL. Here, using full exome or cancer genes-targeted sequencing of 42 ALL samples fro...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nikolaev, Sergey I, Garieri, Marco, Santoni, Federico, Falconnet, Emilie, Ribaux, Pascale, Guipponi, Michel, Murray, Aoife, Groet, Jürgen, Giarin, Emanuela, Basso, Giuseppe, Nizetic, Dean, Antonarakis, Stylianos E
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665216/
https://ncbi.nlm.nih.gov/pubmed/25105841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5654
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