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HSA21 Single-Minded 2 (Sim2) Binding Sites Co-Localize with Super-Enhancers and Pioneer Transcription Factors in Pluripotent Mouse ES Cells

The HSA21 encoded Single-minded 2 (SIM2) transcription factor has key neurological functions and is a good candidate to be involved in the cognitive impairment of Down syndrome. We aimed to explore the functional capacity of SIM2 by mapping its DNA binding sites in mouse embryonic stem cells. ChIP-s...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Letourneau, Audrey, Cobellis, Gilda, Fort, Alexandre, Santoni, Federico, Garieri, Marco, Falconnet, Emilie, Ribaux, Pascale, Vannier, Anne, Guipponi, Michel, Carninci, Piero, Borel, Christelle, Antonarakis, Stylianos E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425456/
https://ncbi.nlm.nih.gov/pubmed/25955728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126475
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