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Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection
The Mre11-Rad50-Xrs2(NBS1) complex plays important roles in the DNA damage response by activating the Tel1(ATM) kinase and catalyzing 5′–3′ resection at DNA double-strand breaks (DSBs). To initiate resection, Mre11 endonuclease nicks the 5′ strands at DSB ends in a reaction stimulated by Sae2(CtIP)....
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6304958/ https://ncbi.nlm.nih.gov/pubmed/30510002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816539115 |
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