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A quasi-integral controller for adaptation of genetic modules to variable ribosome demand

The behavior of genetic circuits is often poorly predictable. A gene’s expression level is not only determined by the intended regulators, but also affected by changes in ribosome availability imparted by expression of other genes. Here we design a quasi-integral biomolecular feedback controller tha...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Huang, Hsin-Ho, Qian, Yili, Del Vecchio, Domitilla
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303309/
https://ncbi.nlm.nih.gov/pubmed/30575748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07899-z
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