Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis

BACKGROUND. Increasing evidence indicates a role for EBV in the pathogenesis of multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the CNS because of defective cytotoxic CD8(+) T cell immunity. We sought to determine the feasibility and safety of treating progressive MS p...

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Pubblicato in:JCI Insight
Autori principali: Pender, Michael P., Csurhes, Peter A., Smith, Corey, Douglas, Nanette L., Neller, Michelle A., Matthews, Katherine K., Beagley, Leone, Rehan, Sweera, Crooks, Pauline, Hopkins, Tracey J., Blum, Stefan, Green, Kerryn A., Ioannides, Zara A., Swayne, Andrew, Aftab, Blake T., Hooper, Kaye D., Burrows, Scott R., Thompson, Kate M., Coulthard, Alan, Khanna, Rajiv
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302936/
https://ncbi.nlm.nih.gov/pubmed/30429369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124714
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