Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization

Alphaviruses are enveloped pathogens that cause arthritis and encephalitis. Here, we report a 4.4-Å cryoelectron microscopy (cryo-EM) structure of eastern equine encephalitis virus (EEEV), an alphavirus that causes fatal encephalitis in humans. Our analysis provides insights into viral entry into ho...

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Udgivet i:Cell Rep
Main Authors: Hasan, S. Saif, Sun, Chengqun, Kim, Arthur S., Watanabe, Yasunori, Chen, Chun-Liang, Klose, Thomas, Buda, Geeta, Crispin, Max, Diamond, Michael S., Klimstra, William B., Rossmann, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302666/
https://ncbi.nlm.nih.gov/pubmed/30540945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.067
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