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IP(3) Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca(2+) to Lysosomes
Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) allow extracellular stimuli to redistribute Ca(2+) from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H(+)-ATPase (V-ATPase) inhibitors, that lysosomes sequester Ca(2+) released by all IP(3)R...
Gorde:
| Argitaratua izan da: | Cell Rep |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Cell Press
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6302550/ https://ncbi.nlm.nih.gov/pubmed/30540949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.064 |
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