IP(3) Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca(2+) to Lysosomes

Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) allow extracellular stimuli to redistribute Ca(2+) from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H(+)-ATPase (V-ATPase) inhibitors, that lysosomes sequester Ca(2+) released by all IP(3)R...

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Publicado en:Cell Rep
Main Authors: Atakpa, Peace, Thillaiappan, Nagendra Babu, Mataragka, Stefania, Prole, David L., Taylor, Colin W.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302550/
https://ncbi.nlm.nih.gov/pubmed/30540949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.064
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