Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Inducible nitric oxide synthase (iNOS) plays a crucial role in controlling growth of Mycobacterium tuberculosis (M.tb), presumably via nitric oxide (NO) mediated killing. Here we show that leukocyte-specific deficiency of NO production, through targeted loss of the iNOS cofactor tetrahydrobiopterin...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: McNeill, Eileen, Stylianou, Elena, Crabtree, Mark J., Harrington-Kandt, Rachel, Kolb, Anna-Lena, Diotallevi, Marina, Hale, Ashley B., Bettencourt, Paulo, Tanner, Rachel, O’Shea, Matthew K., Matsumiya, Magali, Lockstone, Helen, Müller, Julius, Fletcher, Helen A., Greaves, David R., McShane, Helen, Channon, Keith M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302098/
https://ncbi.nlm.nih.gov/pubmed/30573728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07714-9
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