A requirement for Gch1 and tetrahydrobiopterin in embryonic development

INTRODUCTION: GTP cyclohydrolase I (GTPCH) catalyses the first and rate-limiting reaction in the synthesis of the enzymatic cofactor, tetrahydrobiopterin (BH4). Loss of function mutations in the GCH1 gene lead to congenital neurological diseases such as DOPA-responsive dystonia and hyperphenylalanin...

Full description

Saved in:
Bibliographic Details
Published in:Dev Biol
Main Authors: Douglas, Gillian, Hale, Ashley B., Crabtree, Mark J, Ryan, Brent J., Hansler, Alex, Watschinger, Katrin, Gross, Steven S, Lygate, Craig A., Alp, Nicholas J., Channon, Keith M.
Format: Artigo
Language:Inglês
Published: Elsevier 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347993/
https://ncbi.nlm.nih.gov/pubmed/25557619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.12.025
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items