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A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice

BACKGROUND AND PURPOSE: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS‐derived NO and ROS signalling in vascular physiology. To determine the physiological requirement for de novo endothelial cell BH4 synthesis for the vasomotor function of re...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Chuaiphichai, Surawee, Crabtree, Mark J, Mcneill, Eileen, Hale, Ashley B, Trelfa, Lucy, Channon, Keith M, Douglas, Gillian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368052/
https://ncbi.nlm.nih.gov/pubmed/28128438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13728
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