Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

AIMS: GTP cyclohydrolase I catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knock...

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Detalles Bibliográficos
Publicado en:Cardiovasc Res
Main Authors: Douglas, Gillian, Hale, Ashley B, Patel, Jyoti, Chuaiphichai, Surawee, Al Haj Zen, Ayman, Rashbrook, Victoria S, Trelfa, Lucy, Crabtree, Mark J, McNeill, Eileen, Channon, Keith M
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054219/
https://ncbi.nlm.nih.gov/pubmed/29596571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy078
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