Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

AIMS: GTP cyclohydrolase I catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knock...

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Bibliografiska uppgifter
I publikationen:Cardiovasc Res
Huvudupphovsmän: Douglas, Gillian, Hale, Ashley B, Patel, Jyoti, Chuaiphichai, Surawee, Al Haj Zen, Ayman, Rashbrook, Victoria S, Trelfa, Lucy, Crabtree, Mark J, McNeill, Eileen, Channon, Keith M
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054219/
https://ncbi.nlm.nih.gov/pubmed/29596571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy078
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