Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

AIMS: GTP cyclohydrolase I catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knock...

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Publicado en:Cardiovasc Res
Autores principales: Douglas, Gillian, Hale, Ashley B, Patel, Jyoti, Chuaiphichai, Surawee, Al Haj Zen, Ayman, Rashbrook, Victoria S, Trelfa, Lucy, Crabtree, Mark J, McNeill, Eileen, Channon, Keith M
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054219/
https://ncbi.nlm.nih.gov/pubmed/29596571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy078
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