β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling

β transducin repeat-containing protein (β-TrCP) is a Skp1-Cul1-F-box ubiquitin ligase, which plays important roles in controlling numerous signaling pathways. Notably, β-TrCP induces ubiquitination and degradation of inhibitor of NF-κB (IκBα), thus triggering activation of NF-κB signaling. Here, we...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Liu, Jin, Yuan, Yukang, Xu, Jing, Xiao, Kui, Xu, Ying, Guo, Tingting, Zhang, Liting, Wang, Jun, Zheng, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300488/
https://ncbi.nlm.nih.gov/pubmed/30619291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02930
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