Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein

BACKGROUND: It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms that underlie their anti-cancer properties remain unclear. Yes-associated protein, a key effector of Hippo signaling, functions as a transcription coactivator, p...

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Detalhes bibliográficos
Publicado no:Cancer Cell Int
Main Authors: Deng, Li-Juan, Qi, Ming, Peng, Qun-Long, Chen, Min-Feng, Qi, Qi, Zhang, Jia-Yan, Yao, Nan, Huang, Mao-Hua, Li, Xiao-Bo, Peng, Yin-Hui, Liu, Jun-Shan, Fu, Deng-Rui, Chen, Jia-Xu, Ye, Wen-Cai, Zhang, Dong-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299615/
https://ncbi.nlm.nih.gov/pubmed/30574018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0706-9
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