Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance

Daptomycin, a calcium-dependent lipopeptide antibiotic whose full mode of action is still not entirely understood, has become a standard-of-care agent for treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Daptomycin-resistant (DAP-R) S. aureus mutants emerge during therapy, fea...

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Publicado no:mBio
Main Authors: Ernst, Christoph M., Slavetinsky, Christoph J., Kuhn, Sebastian, Hauser, Janna N., Nega, Mulugeta, Mishra, Nagendra N., Gekeler, Cordula, Bayer, Arnold S., Peschel, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299216/
https://ncbi.nlm.nih.gov/pubmed/30563904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01659-18
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