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Alanyl-Phosphatidylglycerol and Lysyl-Phosphatidylglycerol Are Translocated by the Same MprF Flippases and Have Similar Capacities To Protect against the Antibiotic Daptomycin in Staphylococcus aureus

The lysinylation of negatively charged phosphatidylglycerol by MprF proteins reduces the affinity of cationic antimicrobial peptides (CAMPs) for bacterial cytoplasmic membranes and reduces the susceptibility of several Gram-positive bacterial pathogens to CAMPs. MprF of Staphylococcus aureus encompa...

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Detalles Bibliográficos
Main Authors: Slavetinsky, Christoph J., Peschel, Andreas, Ernst, Christoph M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393434/
https://ncbi.nlm.nih.gov/pubmed/22491694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00370-12
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