Regulation of mprF by Antisense RNA Restores Daptomycin Susceptibility to Daptomycin-Resistant Isolates of Staphylococcus aureus

Mutations in mprF have been shown to result in reduced susceptibility to daptomycin and other cationic antibacterials. An mprF antisense-inducible plasmid was constructed and used to demonstrate that depletion of mprF can reestablish susceptibility to daptomycin. Inducing antisense to mprF also resu...

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Bibliografiske detaljer
Main Authors: Rubio, Aileen, Conrad, Mary, Haselbeck, Robert J., G. C., Kedar, Brown-Driver, Vickie, Finn, John, Silverman, Jared A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019644/
https://ncbi.nlm.nih.gov/pubmed/20974866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00429-10
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