Multiple Peptide Resistance Factor (MprF)-mediated Resistance of Staphylococcus aureus against Antimicrobial Peptides Coincides with a Modulated Peptide Interaction with Artificial Membranes Comprising Lysyl-Phosphatidylglycerol

Modification of the membrane lipid phosphatidylglycerol (PG) of Staphylococcus aureus by enzymatic transfer of a l-lysine residue leading to lysyl-PG converts the net charge of PG from −1 to +1 and is thought to confer resistance to cationic antimicrobial peptides (AMPs). Lysyl-PG synthesis and tran...

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Autores principales: Andrä, Jörg, Goldmann, Torsten, Ernst, Christoph M., Peschel, Andreas, Gutsmann, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099686/
https://ncbi.nlm.nih.gov/pubmed/21474443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226886
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