BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired, may lead to genomic instability, cell death and senescence. Damage-induced long non-coding RNAs (dilncRNAs) are transcribed from broken DNA ends and contribute to DNA damage response (DDR) signaling. Here we show...

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Publicat a:Nat Commun
Autors principals: D’Alessandro, Giuseppina, Whelan, Donna Rose, Howard, Sean Michael, Vitelli, Valerio, Renaudin, Xavier, Adamowicz, Marek, Iannelli, Fabio, Jones-Weinert, Corey Winston, Lee, MiYoung, Matti, Valentina, Lee, Wei Ting C., Morten, Michael John, Venkitaraman, Ashok Raraakrishnan, Cejka, Petr, Rothenberg, Eli, d’Adda di Fagagna, Fabrizio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299093/
https://ncbi.nlm.nih.gov/pubmed/30560944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07799-2
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