How does RNase H recognize a DNA.RNA hybrid?

The mechanism of RNase H substrate recognition is proposed from a model of a chemically modified DNA.RNA hybrid Escherichia coli RNase H complex. Site-directed mutagenesis of the enzyme and substrate titration observed by heteronuclear two-dimensional NMR spectra have been carried out. A model compl...

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Autors principals: Nakamura, H, Oda, Y, Iwai, S, Inoue, H, Ohtsuka, E, Kanaya, S, Kimura, S, Katsuda, C, Katayanagi, K, Morikawa, K
Format: Artigo
Idioma:Inglês
Publicat: 1991
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC53170/
https://ncbi.nlm.nih.gov/pubmed/1662398
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