How does RNase H recognize a DNA.RNA hybrid?
The mechanism of RNase H substrate recognition is proposed from a model of a chemically modified DNA.RNA hybrid Escherichia coli RNase H complex. Site-directed mutagenesis of the enzyme and substrate titration observed by heteronuclear two-dimensional NMR spectra have been carried out. A model compl...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53170/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1662398/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.11535 |
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