How does RNase H recognize a DNA.RNA hybrid?

The mechanism of RNase H substrate recognition is proposed from a model of a chemically modified DNA.RNA hybrid Escherichia coli RNase H complex. Site-directed mutagenesis of the enzyme and substrate titration observed by heteronuclear two-dimensional NMR spectra have been carried out. A model compl...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Nakamura, H, Oda, Y, Iwai, S, Inoue, H, Ohtsuka, E, Kanaya, S, Kimura, S, Katsuda, C, Katayanagi, K, Morikawa, K
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1991
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53170/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1662398/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.11535
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