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The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

The E. coli ribosome exit tunnel can accommodate small folded proteins, while larger ones fold outside. It remains unclear, however, to what extent the geometry of the tunnel influences protein folding. Here, using E. coli ribosomes with deletions in loops in proteins uL23 and uL24 that protrude int...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Kudva, Renuka, Tian, Pengfei, Pardo-Avila, Fátima, Carroni, Marta, Best, Robert B, Bernstein, Harris D, von Heijne, Gunnar
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298777/
https://ncbi.nlm.nih.gov/pubmed/30475203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36326
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