Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation

T cell differentiation in the thymus proceeds in an ordered sequence of developmental events characterized by variable expression of CD4 and CD8 coreceptors. Here, we report that immature single-positive (ISP) thymocytes are molecularly distinct from all other T cell populations in the thymus in the...

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Pubblicato in:Cell Rep
Autori principali: Gegonne, Anne, Chen, Qing-Rong, Dey, Anup, Etzensperger, Ruth, Tai, Xuguang, Singer, Alfred, Meerzaman, Daoud, Ozato, Keiko, Singer, Dinah S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298745/
https://ncbi.nlm.nih.gov/pubmed/29972774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.007
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