BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses

BRD4 is a BET family protein that binds acetylated histones and regulates transcription. BET/BRD4 inhibitors block blood cancer growth and inflammation and serve as a new therapeutic strategy. However, the biological role of BRD4 in normal hematopoiesis and inflammation is not fully understood. Anal...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Dey, Anup, Yang, Wenjing, Gegonne, Anne, Nishiyama, Akira, Pan, Richard, Yagi, Ryoji, Grinberg, Alex, Finkelman, Fred D, Pfeifer, Karl, Zhu, Jinfang, Singer, Dinah, Zhu, Jun, Ozato, Keiko
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443207/
https://ncbi.nlm.nih.gov/pubmed/30842097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100293
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