A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus.

The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and therapeutics to limit/prevent outbreaks. Host antibodies against EBOV are critical for controlling disease, and recombinant monoclonal antibodies (mAbs) can protect from infection. However, antibodies mediate an a...

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Publicat a:Cell Host Microbe
Autors principals: Gunn, Bronwyn M, Yu, Wen-Han, Karim, Marcus M, Brannan, Jennifer M, Herbert, Andrew S, Wec, Anna Z, Halfmann, Peter J, Fusco, Marnie L, Schendel, Sharon L, Gangavarapu, Karthik, Krause, Tyler, Qiu, Xiangguo, He, Shinhua, Das, Jishnu, Suscovich, Todd J, Lai, Jonathan, Chandran, Kartik, Zeitlin, Larry, Crowe, James E, Lauffenburger, Douglas, Kawaoka, Yoshihiro, Kobinger, Gary P, Andersen, Kristian G, Dye, John M, Saphire, Erica Ollmann, Alter, Galit
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298217/
https://ncbi.nlm.nih.gov/pubmed/30092199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.07.009
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