A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus.

The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and therapeutics to limit/prevent outbreaks. Host antibodies against EBOV are critical for controlling disease, and recombinant monoclonal antibodies (mAbs) can protect from infection. However, antibodies mediate an a...

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Publicado no:Cell Host Microbe
Main Authors: Gunn, Bronwyn M, Yu, Wen-Han, Karim, Marcus M, Brannan, Jennifer M, Herbert, Andrew S, Wec, Anna Z, Halfmann, Peter J, Fusco, Marnie L, Schendel, Sharon L, Gangavarapu, Karthik, Krause, Tyler, Qiu, Xiangguo, He, Shinhua, Das, Jishnu, Suscovich, Todd J, Lai, Jonathan, Chandran, Kartik, Zeitlin, Larry, Crowe, James E, Lauffenburger, Douglas, Kawaoka, Yoshihiro, Kobinger, Gary P, Andersen, Kristian G, Dye, John M, Saphire, Erica Ollmann, Alter, Galit
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298217/
https://ncbi.nlm.nih.gov/pubmed/30092199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.07.009
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