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Mutant voltage-gated Na(+) channels can exert a dominant negative effect through coupled gating
Mutations in voltage-gated Na(+) channels have been linked to several channelopathies leading to a wide variety of diseases including cardiac arrhythmias, epilepsy, and myotonia. We have previously demonstrated that voltage-gated Na(+) channel (Na(v))1.5 trafficking-deficient mutant channels could l...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6297814/ https://ncbi.nlm.nih.gov/pubmed/30118344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00721.2017 |
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