A Destructive Interaction Mechanism Accounts for Dominant-Negative Effects of Misfolded Mutants of Voltage-Gated Calcium Channels

Channelopathies are often linked to defective protein folding and trafficking. Among them, the calcium channelopathy episodic ataxia type-2 (EA2) is an autosomal dominant disorder related to mutations in the pore-forming Ca(v)2.1 subunit of P/Q-type calcium channels. Although EA2 is linked to loss o...

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Vydáno v:J Neurosci
Hlavní autoři: Mezghrani, Alexandre, Monteil, Arnaud, Watschinger, Katrin, Sinnegger-Brauns, Martina J., Barrère, Christian, Bourinet, Emmanuel, Nargeot, Joël, Striessnig, Jörg, Lory, Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670939/
https://ncbi.nlm.nih.gov/pubmed/18434528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2844-07.2008
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