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Curcumin, but not curcumin-glucuronide, inhibits Smad-signaling in TGFβ-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues
Breast cancer (BCa) bone metastases (BMETs) drive osteolysis via a feed-forward loop involving tumoral secretion of osteolytic factors (e.g., PTHrP) induced by bone matrix-derived growth factors (e.g., TGFβ). In prior experiments, turmeric-derived curcumin inhibited in vivo BMET progression and in v...
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| Publicado no: | J Nutr Biochem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6296872/ https://ncbi.nlm.nih.gov/pubmed/30393127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2018.09.021 |
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