LILRB4 signaling in leukemia cells mediates T cell suppression and tumor infiltration

Immune checkpoint blockade therapy has been successful in treating some types of cancers but has not shown clinical benefits for treating leukemia (1). This result suggests that leukemia exploits unique escape mechanisms. Certain immune inhibitory receptors that are expressed by normal immune cells...

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Pubblicato in:Nature
Autori principali: Deng, Mi, Gui, Xun, Kim, Jaehyup, Xie, Li, Chen, Weina, Li, Zunling, He, Licai, Chen, Yuanzhi, Chen, Heyu, Luo, Weiguang, Lu, Zhigang, Xie, Jingjing, Churchill, Hywyn, Xu, Yixiang, Zhou, Zhan, Wu, Guojin, Yu, Chenyi, John, Samuel, Hirayasu, Kouyuki, Nguyen, Nam, Liu, Xiaoye, Huang, Fangfang, Li, Leike, Deng, Hui, Tang, Haidong, Sadek, Ali H., Zhang, Lingbo, Huang, Tao, Zou, Yizhou, Chen, Benjamin, Zhu, Hong, Arase, Hisashi, Xia, Ningshao, Jiang, Youxing, Collins, Robert, You, M. James, Homsi, Jade, Unni, Nisha, Lewis, Cheryl, Chen, Guo-Qiang, Fu, Yang-Xin, Liao, X. Charlene, An, Zhiqiang, Zheng, Junke, Zhang, Ningyan, Zhang, Cheng Cheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296374/
https://ncbi.nlm.nih.gov/pubmed/30333625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0615-z
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