LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells

We recently demonstrated that leukocyte Ig-like receptor 4 (LILRB4) expressed by monocytic acute myeloid leukemia (AML) cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular domain. The cytoplasmic domain of LILRB4 contains three immunoreceptor tyrosine-based inhibito...

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Gepubliceerd in:Cell Mol Immunol
Hoofdauteurs: Li, Zunling, Deng, Mi, Huang, Fangfang, Jin, Changzhu, Sun, Shuang, Chen, Heyu, Liu, Xiaoye, He, Licai, Sadek, Ali H., Zhang, Cheng Cheng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052276/
https://ncbi.nlm.nih.gov/pubmed/31700117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0321-2
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