LILRB4 signaling in leukemia cells mediates T cell suppression and tumor infiltration

Immune checkpoint blockade therapy has been successful in treating some types of cancers but has not shown clinical benefits for treating leukemia (1). This result suggests that leukemia exploits unique escape mechanisms. Certain immune inhibitory receptors that are expressed by normal immune cells...

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Опубликовано в: :Nature
Главные авторы: Deng, Mi, Gui, Xun, Kim, Jaehyup, Xie, Li, Chen, Weina, Li, Zunling, He, Licai, Chen, Yuanzhi, Chen, Heyu, Luo, Weiguang, Lu, Zhigang, Xie, Jingjing, Churchill, Hywyn, Xu, Yixiang, Zhou, Zhan, Wu, Guojin, Yu, Chenyi, John, Samuel, Hirayasu, Kouyuki, Nguyen, Nam, Liu, Xiaoye, Huang, Fangfang, Li, Leike, Deng, Hui, Tang, Haidong, Sadek, Ali H., Zhang, Lingbo, Huang, Tao, Zou, Yizhou, Chen, Benjamin, Zhu, Hong, Arase, Hisashi, Xia, Ningshao, Jiang, Youxing, Collins, Robert, You, M. James, Homsi, Jade, Unni, Nisha, Lewis, Cheryl, Chen, Guo-Qiang, Fu, Yang-Xin, Liao, X. Charlene, An, Zhiqiang, Zheng, Junke, Zhang, Ningyan, Zhang, Cheng Cheng
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296374/
https://ncbi.nlm.nih.gov/pubmed/30333625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0615-z
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