Synthesis, Anti-HBV, and Anti-HIV Activities of 3′-Halogenated Bis(hydroxymethyl)-cyclopentenyladenines

[Image: see text] Synthesis of 3′-halogeno analogues (5a–d) of 9-[c-4,t-5-bis(hydroxymethyl)-cyclopent-2-en-r-1-yl]-9H-adenine (BCA, 3) was accomplished by means of dual utilization of the vinyl sulfone functional moieties in both 10 and 16 utilizing a S(N)2′ conjugate-addition reaction and a sulfur...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kumamoto, Hiroki, Imoto, Shuhei, Amano, Masayuki, Kuwata-Higashi, Nobuyo, Baba, Masanori, Mitsuya, Hiroaki, Odanaka, Yuki, Shimbara Matsubayashi, Satoko, Tanaka, Hiromichi, Haraguchi, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295849/
https://ncbi.nlm.nih.gov/pubmed/30613328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00374
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