Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine In Vitro

2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T) has been identified as a novel nucleoside analog with potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity and weak cytotoxicity in cell cultures. 4′-Ed4T proved to be 5- to 10-fold more active than its structurally rel...

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Detalhes bibliográficos
Main Authors: Nitanda, Takao, Wang, Xin, Kumamoto, Hiroki, Haraguchi, Kazuhiro, Tanaka, Hiromichi, Cheng, Yung-Chi, Baba, Masanori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196241/
https://ncbi.nlm.nih.gov/pubmed/16048947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3355-3360.2005
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