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Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD

The dihydroorotase (DHOase) domain of the multifunctional protein carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase (CAD) catalyzes the third step in the de novo biosynthesis of pyrimidine nucleotides in animals. The crystal structure of the DHOase domain of human CAD...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: del Caño-Ochoa, Francisco, Grande-García, Araceli, Reverte-López, María, D'Abramo, Marco, Ramón-Maiques, Santiago
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295737/
https://ncbi.nlm.nih.gov/pubmed/30315107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005494
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