SphK1/S1P mediates TGF-β1-induced proliferation of pulmonary artery smooth muscle cells and its potential mechanisms

The upregulation of Sphingosine kinase 1 (SphK1) expression and accompanied sphingosine-1-phosphate (S1P) production have been reported to contribute to the proliferation of pulmonary artery smooth muscle cells (PASMC) and pulmonary arterial remodeling. However, the molecular mechanisms of SphK1/S1P...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Pulm Circ
Hauptverfasser: Wang, Jian, Feng, Wei, Li, Fangwei, Shi, Wenhua, Zhai, Cui, Li, Shaojun, Zhu, Yanting, Yan, Xin, Wang, Qingting, Liu, Lu, Xie, Xinming, Li, Manxiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295694/
https://ncbi.nlm.nih.gov/pubmed/30430898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2045894018816977
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