Rare but recurrent ROS1 fusions resulting from chromosome 6q22 microdeletions are targetable oncogenes in glioma

BACKGROUND: Gliomas, a genetically heterogeneous group of primary central nervous system tumors, continue to pose a significant clinical challenge. Discovery of chromosomal rearrangements involving kinase genes has enabled precision therapy, and improved outcomes in several malignancies. EXPERIMENTA...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Davare, Monika A., Henderson, Jacob J., Agarwal, Anupriya, Wagner, Jacob P., Iyer, Sudarshan R., Shah, Nameeta, Woltjer, Randy, Somwar, Romel, Gilheeney, Stephen W., DeCarvalo, Ana, Mikkelson, Tom, Van Meir, Erwin G., Ladanyi, Marc, Druker, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295214/
https://ncbi.nlm.nih.gov/pubmed/30171048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1052
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