Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

The rapidly growing recognition of the role of oncogenic ROS1 fusion proteins in the malignant transformation of multiple cancers, including lung adenocarcinoma, cholangiocarcinoma, and glioblastoma, is driving efforts to develop effective ROS1 inhibitors for use as molecularly targeted therapy. Usi...

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Detalhes bibliográficos
Main Authors: Davare, Monika A., Saborowski, Anna, Eide, Christopher A., Tognon, Cristina, Smith, Rebecca L., Elferich, Johannes, Agarwal, Anupriya, Tyner, Jeffrey W., Shinde, Ujwal P., Lowe, Scott W., Druker, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845150/
https://ncbi.nlm.nih.gov/pubmed/24218589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319583110
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