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UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells

The best-known function of ubiquitin-like (UBL) domains in proteins is to enable their binding to 26S proteasomes. The proteasome-associated deubiquitinating enzyme Usp14/UBP6 contains an N-terminal UBL domain and is an important regulator of proteasomal activity. Usp14 by itself represses multiple...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kim, Hyoung Tae, Goldberg, Alfred L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294929/
https://ncbi.nlm.nih.gov/pubmed/30487212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808731115
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