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Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation

Although ubiquitination is widely assumed to be the only regulated step in the ubiquitin–proteasome pathway, recent studies have demonstrated several important mechanisms that regulate the activities of the 26S proteasome. Most proteasomes in cells are inactive but, upon binding a ubiquitinated subs...

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Pubblicato in:Biomolecules
Autori principali: Goldberg, Alfred L., Kim, Hyoung Tae, Lee, Donghoon, Collins, Galen Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8224753/
https://ncbi.nlm.nih.gov/pubmed/34067263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11060779
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