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Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation

During protein degradation by the ubiquitin–proteasome pathway, latent 26S proteasomes in the cytosol must assume an active form. Proteasomes are activated when ubiquitylated substrates bind to them and interact with the proteasome-bound deubiquitylase Usp14/Ubp6. The resulting increase in the prote...

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Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Collins, Galen A., Goldberg, Alfred L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060731/
https://ncbi.nlm.nih.gov/pubmed/32071216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915534117
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