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Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation
During protein degradation by the ubiquitin–proteasome pathway, latent 26S proteasomes in the cytosol must assume an active form. Proteasomes are activated when ubiquitylated substrates bind to them and interact with the proteasome-bound deubiquitylase Usp14/Ubp6. The resulting increase in the prote...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7060731/ https://ncbi.nlm.nih.gov/pubmed/32071216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915534117 |
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